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Physiology 19: 271-276, 2004; doi:10.1152/physiol.00010.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 5, 271-276, October 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Why Calcium-Stimulated Adenylyl Cyclases?

Gregory D. Ferguson and Daniel R. Storm

Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280

dstorm{at}u.washington.edu

The Ca2+/calmodulin-stimulated adenylyl cyclases, AC1 and AC8, play a critical role in several forms of neuroplasticity, including long-lasting long-term potentiation (L-LTP) and long-term memory (LTM). By coupling neuronal activity and Ca2+ increases to the production of cAMP, AC1 and AC8 activate cAMP-dependent signal transduction and transcriptional pathways critical for L-LTP and LTM.




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