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Physiology 19: 277-284, 2004; doi:10.1152/physiol.00008.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 5, 277-284, October 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Connexins: Gaps in Our Knowledge of Vascular Function

Xavier F. Figueroa, Brant E. Isakson and Brian R. Duling

Department of Molecular Physiology and Biological Physics, Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908

Gap junctions are common features in the vasculature, long thought to provide a pathway for cell-cell signaling. Emerging understanding of the gap-junctional proteins (connexins) and new tools for their investigation now offer the opportunity to explore the vital role that the gap junctions may play in cardiovascular homeostasis and pathophysiology.




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