Physiology Journal of Neurophysiology
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Physiology 19: 285-292, 2004; doi:10.1152/physiol.00011.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 5, 285-292, October 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Voltage-Gated Potassium Channels in Cell Proliferation

Luis A. Pardo

Max-Planck Institute for Experimental Medicine, 37075 Göttingen, Germany

lpardo{at}gwdg.de

It is commonly accepted that cells require K+ channels to proliferate. The role(s) of K+ channels in the process is, however, poorly understood. Cloning of K+ channel genes opened the possibility to approach this problem in a way more independent from pharmacological tools. Recent work shows that several identified K+ channels are important in both physiological and pathological cell proliferation and open a promising pathway for novel targeted therapies.




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