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REVIEW

Moving Forward: Mechanisms of Chemoattractant Gradient Sensing

Jonathan Franca-Koh and Peter N. Devreotes

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

pnd{at}jhmi.edu

Cells use an internal compass to sense the direction of chemoattractant gradients. This is used to bias pseudopod extension at the front of the cell and to orient cell polarization. Recent studies have highlighted the important roles played by phosphoinositide-3,4,5-triphosphate and small G proteins, but many questions remain.

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