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Physiology 19: 309-314, 2004; doi:10.1152/physiol.00022.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 5, 309-314, October 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

The Nuclear Envelope and Human Disease

Antoine Muchir and Howard J. Worman

Departments of Medicine and of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032

hjw14{at}columbia.edu

Mutations in nuclear lamins A and C, intermediate filament proteins of the nuclear envelope, cause diseases affecting various tissues and the aging process. We review what is known about nuclear lamin function and the different diseases caused by mutations in lamins A and C and associated inner nuclear membrane proteins.




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