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Physiology 19: 355-361, 2004; doi:10.1152/physiol.00018.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 6, 355-361, December 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

ARC Channels: A Novel Pathway for Receptor-Activated Calcium Entry

Trevor J. Shuttleworth, Jill L. Thompson and Olivier Mignen

Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642

trevor_shuttleworth{at}urmc.rochester.edu

In many nonexcitable cells, stimulation with low agonist concentrations specifically activates Ca2+ entry via arachidonic acid-regulated, highly Ca2+-selective ARC channels. Only at high agonist concentrations are the more widely studied store-operated channels activated, producing sustained elevated cytosolic Ca2+ concentration signals. These signals activate calcineurin, which in turn inhibits the ARC channels, resulting in a "reciprocal regulation" of these two distinct Ca2+-entry pathways that may have important functional implications for the cell.




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