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Physiology 19: 370-376, 2004; doi:10.1152/physiol.00026.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 6, 370-376, December 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Surprising Versatility of Na+-Glucose Cotransporters: SLC5

Ernest M. Wright, Donald D. F. Loo, Bruce A. Hirayama and Eric Turk

Department of Physiology, The David Geffen School of Medicine at the University of California-Los Angeles, Los Angeles, California 90095-1751

ewright{at}mednet.ucla.edu http://149.142.237.182/

SLC5 is an ancient gene family with 11 members in the human genome. These membrane proteins have diverse, multiple functions ranging from actively transporting solutes, ions, and water, to channeling water and urea, to sensing glucose in cholinergic neurons. Metabolic disorders have been identified that are associated with congenital mutations in two of the human genes.




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