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News Physiol Sci 2: 16-18, 1987;
1548-9213/87 $5.00
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News in Physiological Sciences, Vol 2, 16-18, Copyright © 1987 by International Union of Physiological Sciences


ARTICLES

When Capillary Permeability Increases

C Crone

Capillary permeability is usually ascribed to a number of "small" pores. In this article the small-pore pathway is identified as interruptions in the tight junctions between endothelial cells. Modulation of capillary permeability involves control of tight junction permeability with cytosolic Ca2+ as the important signal molecule. Actin and myosin filaments are probably involved in the process, which may implicate subtle changes in cell shape.





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