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News Physiol Sci 2: 18-22, 1987;
1548-9213/87 $5.00
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News in Physiological Sciences, Vol 2, 18-22, Copyright © 1987 by International Union of Physiological Sciences

ARTICLES

Endothelium and the Control of Vascular Tissue

PM Vanhoutte

Endothelial cells contribute more than an inside lining of blood vessels. They react to mechanical forces and to a number of substances, either locally produced or circulating in blood, that cause the release of one or more as yet unidentified endothelium-derived relaxing factors. Other agents, including stretch and blood pressure, evoke endothelium-dependent contraction of blood vessels. Such mechanisms make endothelial cells ideal sensors to monitor changes in the flow and composition of the blood.


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