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News Physiol Sci 2: 26-29, 1987;
1548-9213/87 $5.00
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News in Physiological Sciences, Vol 2, 26-29, Copyright © 1987 by International Union of Physiological Sciences

ARTICLES

Control of Sodium Excretion: The Kidney Produces Under Pressure

FG Knox and JP Granger

Sodium excretion is controlled by an integration of physical, neural, and hormonal regulatory systems. The major systems involved in retention of sodium include the renin-angiotensin-aldosterone system and the sympathetic nervous system. In response to increased sodium intake, the sodium-retaining systems are inhibited and natriuretic hormones are activated. Pressures and flows within the microcirculation of the kidney, in concert with neural and hormonal systems, are important effector mechanisms that work to regulate sodium excretion.


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