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News Physiol Sci 2: 61-64, 1987;
1548-9213/87 $5.00
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News in Physiological Sciences, Vol 2, 61-64, Copyright © 1987 by International Union of Physiological Sciences

ARTICLES

Endothelium-Derived Relaxing Factor: In Search of the Endogenous Nitroglycerin

I Fridovich, P-O Hagen and JJ Murray

A mediator released from vascular endothelium is characterized by a potent relaxing activity on vascular smooth muscle as well as an inhibitory activity on platelet aggregation. It is distinctly different from prostacyclin and is referred to as endothelial-derived relaxing factor or EDRF. It is extremely labile, but the recent chemical stabilization of the elusive factor should help unravel its identity and define the activity of this important physiological regulator.


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