Physiology AJP: Lung Cellular and Molecular Physiology
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News Physiol Sci 2: 107-111, 1987;
1548-9213/87 $5.00
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News in Physiological Sciences, Vol 2, 107-111, Copyright © 1987 by International Union of Physiological Sciences

ARTICLES

Mammary Cultures on Floating Gels: A Model System for Mammary Function

MC Neville

Cultures of mammary epithelium on collagen gels can be induced to secrete the normal complement of milk proteins if the gels are released from the culture dish, allowing them to contract. During the contraction the epithelial cells undergo a shape change from flattened to columnar that initiates secretion of milk proteins. These floating cultures are dependent on hormones and offer a valuable model system for the study of milk secretion and its regulation.




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