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News Physiol Sci 2: 82-85, 1987;
1548-9213/87 $5.00
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News in Physiological Sciences, Vol 2, 82-85, Copyright © 1987 by International Union of Physiological Sciences

ARTICLES

Calcium-Dependent Proteases: A Prevalent Proteolytic System of Uncertain Function

GN DeMartino and DE Croall

Calcium-dependent proteases are found in a wide variety of tissues from many animal species. They are intracellular enzymes that for activation require calcium in the micromolar range. In addition to the calcium dependence, two regulatory proteins have been identified, one an inhibitor and one an activator. These interactions indicate a highly complex role for calcium-dependent proteolysis in the intracellular processing of proteins.




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