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News Physiol Sci 2: 93-97, 1987;
1548-9213/87 $5.00
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News in Physiological Sciences, Vol 2, 93-97, Copyright © 1987 by International Union of Physiological Sciences

ARTICLES

Elimination of Functional Synapses During Development of the Nervous System

J Mariani and N Delhaye-Bochaud

Prevailing views of how axonal projections and synapses are formed during development have changed during the last 2 decades. In many structures abundant collaterals and redundant synapses are first formed, then supernumerary axonal branches are withdrawn, and most synaptic contacts are eliminated. These phenomena involve competition between axon terminals, trophic feedback between pre- and postsynaptic partners, and modulation by factors such as functional activity.


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