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News Physiol Sci 2: 97-100, 1987;
1548-9213/87 $5.00
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News in Physiological Sciences, Vol 2, 97-100, Copyright © 1987 by International Union of Physiological Sciences

ARTICLES

How Plasma Macromolecules Cross the Endothelium

M Simionescu, L Ghitescu, A Fixman and N Simionescu

Plasma macromolecules can, in some tissues, cross the capillary wall and enter the interstitial space by a specific mechanism of transcytosis in which a macromolecule is first recognized by its receptor on the luminal surface of endothelial cells. A cluster of receptors bearing their cargo is confined to a vesicle that crosses the cells and discharges the macromolecules on the abluminal surface. The process may be especially important for transport of large molecules, such as albumin, transferrin, insulin, and low-density-lipoprotein, to the cells where they are needed.


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