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News Physiol Sci 2: 160-164, 1987;
1548-9213/87 $5.00
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News in Physiological Sciences, Vol 2, 160-164, Copyright © 1987 by International Union of Physiological Sciences

ARTICLES

Formate: A Critical Intermediate for Chloride Transport in the Proximal Tubule

LP Karniski and PS Aronson

Recent experiments unexpectedly suggest that formate plays a critical role in chloride transport across cell membranes. In particular, active uptake of chloride in the renal proximal tubule cell occurs by chloride-formate exchange. Formate recycles from lumen to cell via nonionic diffusion of uncharged formic acid. In this manner, small amounts of formate can facilitate resorption of large quantities of chloride.




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