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News Physiol Sci 2: 179-182, 1987;
1548-9213/87 $5.00
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News in Physiological Sciences, Vol 2, 179-182, Copyright © 1987 by International Union of Physiological Sciences

ARTICLES

Dependence of Cardiac Contractility on Myofibrillar Calcium Sensitivity

JC Ruegg

In the heart, contractility may be varied over a wide range. It is determined mainly by the myoplasmic free calcium ion concentration. However, alteration of the responsiveness of the myofilaments to calcium may also be important in regulating cardiac contractility, in particular following changes in sarcomere length, or in hypoxia, or after interventions with certain novel cardiotonic drugs.




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