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News Physiol Sci 2: 182-186, 1987;
1548-9213/87 $5.00
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News in Physiological Sciences, Vol 2, 182-186, Copyright © 1987 by International Union of Physiological Sciences

ARTICLES

The Chemical Transmission Mechanism of Excitation-Contraction Coupling in Skeletal Muscle

J Vergara and K Asotra

There is a temperature-dependent lag between depolarization of transverse tubules by the action potential and onset of calcium release from the sacromplasmic reticulum that reveals the occurrence of a chemical step in excitation-contraction coupling. Recent studies suggest that in vertebrate muscle inositol 1,4,5-trisphosphate may act as a chemical link in this process.




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