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Physiology 20: 36-42, 2005; doi:10.1152/physiol.00033.2004
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Physiology, Vol. 20, No. 1, 36-42, February 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Endothelial Progenitor Cells for Vasculogenesis

Satoshi Murasawa1 and Takayuki Asahara1,2

1 Department of Regenerative Medicine and Research, Kobe Institute of Biomedical Research and Innovation/RIKEN, Center for Developmental Biology, Kobe; and
2 Department of Regenerative Medicine Science, Tokai University School of Medicine, Isehara, Japan

asa777{at}aol.com murasawa{at}ibri-kobe.org

Postnatal vasculogenesis is considered to be involved in neovascularization of adult tissues, because bone marrow-derived endothelial progenitor cells (EPCs) were isolated from circulating mononuclear cells in peripheral blood and were shown to incorporate into sites of physiological and pathological neovascularization and to differentiate into mature endothelial cells. EPCs might have an attractive potential therapeutic application for cardiovascular ischemic diseases as a novel cell-based strategy mainly via a vasculogenesis mechanism.




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