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Physiology 20: 43-53, 2005; doi:10.1152/physiol.00040.2004
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 1, 43-53, February 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Molecular Control of Cytoskeletal Mechanics by Hemodynamic Forces

Brian P. Helmke

Department of Biomedical Engineering and Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia

helmke{at}virginia.edu

The endothelium at the interface between blood and tissue acts as a primary transducer of local hemodynamic forces into signals that maintain physiological function or initiate pathological processes in vessel walls. Rapid intracellular spatial gradients of structural dynamics and signaling molecule activity suggest that mechanical cues at the molecular level guide cellular mechanotransduction and adaptation to shear stress profiles.




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