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Physiology 20: 54-59, 2005; doi:10.1152/physiol.00048.2004
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 1, 54-59, February 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

A Role for the Wilms’ Tumor Protein WT1 in Organ Development

Holger Scholz and Karin M. Kirschner

Johannes-Müller-Institut für Physiologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

holger.scholz{at}charite.de

Wilms’ tumor (nephroblastoma) represents a unique example of an aberrant kidney formation that can result from mutations in a tumor suppressor gene, Wilms’ tumor 1 (WT1). Targeted gene inactivation in mice testifies that WT1 is a master switch for the development of the genitourinary system and other organs.




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