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Physiology 20: 134-139, 2005; doi:10.1152/physiol.00053.2004
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 2, 134-139, April 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

SGK1: A Rapid Aldosterone-Induced Regulator of Renal Sodium Reabsorption

James A. McCormick, Vivek Bhalla, Alan C. Pao and David Pearce

Departments of Medicine and Cellular and Molecular Pharmacology, University of California-San Francisco, San Francisco, California

pearced{at}medicine.ucsf.edu

Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.




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