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Physiology 20: 96-101, 2005; doi:10.1152/physiol.00045.2004
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 2, 96-101, April 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

How Does the Kidney Filter Plasma?

Karl Tryggvason1 and Jorma Wartiovaara2

1 Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden; and
2 Institute of Biotechnology, University of Helsinki, Helsinki, Finland

karl.tryggvason{at}mbb.ki.se jorma.wartiovaara{at}helsinki.fi

The kidneys filter the plasma in special filtration units—glomeruli—and thereby excrete low-molecular-weight waste products into the urine. The mechanisms of glomerular filtration have been a matter of controversy for several decades, but recent data have revealed new details about the molecular nature of the filter and have demonstrated a central role for the podocyte slit diaphragm in the filtration process.




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