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Physiology 20: 201-210, 2005; doi:10.1152/physiol.00006.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 3, 201-210, June 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Synaptic Depression as a Timing Device

Lucinda A. Grande3 and William J. Spain1,2,4

1 Department of Physiology and Biophysics,
2 Department of Neurology, and
3 Department of Medicine, University of Washington; and
4 Veterans Affairs Puget Sound Health Care System, Seattle, Washington

spain{at}u.washington.edu

A depressing synapse transforms a time interval into a voltage amplitude. The effect of that transformation on the output of the neuron and network depends on the kinetics of synaptic depression and properties of the postsynaptic neuron and network. Using as examples neural circuits that incorporate depressing synapses, we show how short-term depression can contribute to a surprising variety of time-dependent computational and behavioral tasks.






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