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Physiology 20: 225-231, 2005; doi:10.1152/physiol.00013.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 4, 225-231, August 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Biogenic Amine Neurotransmitter Transporters: Just When You Thought You Knew Them

Randy D. Blakely, Louis J. DeFelice and Aurelio Galli

Departments of Pharmacology, Molecular Physiology and Biophysics, and Psychiatry, and Center for Molecular Neuroscience, Vanderbilt School of Medicine, Nashville, Tennessee

randy.blakely{at}vanderbilt.edu

Plasma membrane transporters have long been known to support the reuptake of biogenic amine neurotransmitters following release in the central and peripheral nervous systems. Using high-resolution imaging, patch-clamp and amperometric approaches, as well as molecular manipulations of transporter-regulatory pathways, surprising new details have been uncovered as to how transporters work and are influenced by signaling pathways and psychostimulants.




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