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Physiology 20: 252-259, 2005; doi:10.1152/physiol.00010.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 4, 252-259, August 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Genomes Optimize Reproduction: Aging as a Consequence of the Developmental Program

João Pedro de Magalhães and George M. Church

Department of Genetics, Harvard Medical School, Boston, Massachusetts

jp{at}senescence.info

Natural selection shapes genomes for reproduction, not for postreproductive survival. One hypothesis then is that the developmental program, optimized for reproduction, inadvertently regulates aging in mammals. Herein we review, revive, and refine the developmental theory of aging. Implications and experimental approaches for studying the progressive deterioration of physiological function that we call aging are also discussed.




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