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Physiology 20: 316-325, 2005; doi:10.1152/physiol.00022.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 5, 316-325, October 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

A Strategy for Integrative Computational Physiology

Peter Hunter and Poul Nielsen

Bioengineering Institute, University of Auckland, Auckland, New Zealand

p.hunter{at}auckland.ac.nz

Organ function (the heart beat for example) can only be understood through knowledge of molecular and cellular processes within the constraints of structure-function relations at the tissue level. A quantitative modeling framework that can deal with these multiscale issues is described here under the banner of the International Union of Physiological Sciences Physiome Project.




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