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Physiology 20: 340-348, 2005; doi:10.1152/physiol.00019.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 5, 340-348, October 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Molecular Pathways Leading to Cancer Cachexia

Michael J. Tisdale

Cancer Biochemistry, School of Life and Health Sciences, Aston University, Birmingham, United Kingdom

m.j.tisdale{at}aston.ac.uk

Loss of body weight in cancer patients strongly influences morbidity and mortality. Recent studies have suggested that both tumor and host factors play a major role in tissue catabolism in cachexia, leading to upregulation of degradative pathways in both skeletal muscle and adipose tissue.




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