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Physiology 20: 349-356, 2005; doi:10.1152/physiol.00025.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 5, 349-356, October 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

The Bone Marrow Vascular Niche: Home of HSC Differentiation and Mobilization

Hans-Georg Kopp, Scott T. Avecilla, Andrea T. Hooper and Shahin Rafii

Weill Medical College of Cornell University, New York, New York

srafii{at}med.cornell.edu

The bone marrow vasuclar niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis.




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