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Physiology 20: 374-381, 2005; doi:10.1152/physiol.00028.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 6, 374-381, December 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

EMERGING TOPICS

Ecto-ADP-ribose Transferases: Cell-Surface Response to Local Tissue Injury

Anna Zolkiewska

Department of Biochemistry, Kansas State University, Manhattan, Kansas

zolkiea{at}ksu.edu

Ecto-ADP-ribose transferases (ecto-ARTs) catalyze the transfer of ADP-ribose from NAD+ to arginine residues in cell-surface proteins. Since the concentration of extracellular NAD+ is very low under normal physiological conditions but rises significantly upon tissue injury or membrane stress, it is postulated that the main role of ecto-ARTs is to ADP-ribosylate and regulate the function of certain membrane receptors in response to elevated levels of NAD+.




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