Physiology AJP: Heart and Circulatory Physiology
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Physiology 20: 408-416, 2005; doi:10.1152/physiol.00031.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 6, 408-416, December 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

The KCNQ1 Potassium Channel: From Gene to Physiological Function

Thomas Jespersen1, Morten Grunnet1,2 and Søren-Peter Olesen1,2

1 Department of Medical Physiology and Danish Arrhythmia Research Center, The Panum Institute, University of Copenhagen, Copenhagen, Denmark, and
2 NeuroSearch, Ballerup, Denmark

The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues. KCNQ1 channels in these tissues are tightly regulated by auxiliary proteins and accessory factors, capable of modulating the properties of the channel complexes. This paper reviews the current knowledge about the KCNQ1 channel with a major focus on interacting proteins and physiological functions.




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