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REVIEW

Role of Acid/Base Transporters in the Male Reproductive Tract and Potential Consequences of Their Malfunction

Nuria Pastor-Soler, Christine Piétrement and Sylvie Breton

Program in Membrane Biology/Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts

sbreton{at}partners.org

Acid/base transporters play a key role in establishing an acidic luminal environment for sperm maturation and storage in the male reproductive tract. Impairment of the acidification capacity of the epididymis, via either genetic mutations or exposure to environmental factors, may have profound consequences on male fertility.

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