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Physiology 20: 429-438, 2005; doi:10.1152/physiol.00032.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 6, 429-438, December 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Acid Acclimation by Helicobacter pylori

George Sachs, David L. Weeks, Yi Wen, Elizabeth A. Marcus and David R. Scott

Laboratory of Membrane Biology, David Geffen School of Medicine at the University of California-Los Angeles and Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California

Klaus Melchers

Altana Research Institute, Boston, Massachusetts

gsachs{at}ucla.edu

Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, UreI, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to ~6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.




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