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Physiology 21: 61-68, 2006; doi:10.1152/physiol.00139.2005
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Physiology, Vol. 21, No. 1, 61-68, February 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Ste20-Type Kinases: Evolutionarily Conserved Regulators of Ion Transport and Cell Volume

Kevin Strange and Jerod Denton

Departments of Anesthesiology, Molecular Physiology and Biophysics, and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee

Keith Nehrke

Department of Medicine, Nephrology Division, University of Rochester Medical Center, Rochester, New York

kevin.strange{at}vanderbilt.edu

Ste20 serine/threonine kinases regulate fundamental cellular processes including the cell cycle, apoptosis, and stress responses. Recent studies in Caenorhabditis elegans and mammals demonstrate that Ste20 kinases also function in cell volume sensing and Cl– transport regulation. Yeast Ste20 initiates a shrinkage activated MAPK cascade that regulates organic osmolyte accumulation. Ste20 kinases thus play evolutionarily conserved roles in cellular volume sensing and regulation. They may also function in systemic osmotic homeostasis and to link cell-cycle events with cell volume.




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