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Physiology 21: 115-123, 2006; doi:10.1152/physiol.00052.2005
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 2, 115-123, April 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

The Ins and Outs of Iron Homeostasis

Adriana Donovan1,*, Cindy N. Roy1,* and Nancy C. Andrews1,2

1 Children’s Hospital Boston, Dana-Farber Cancer Institute, Harvard Medical School, and
2 Howard Hughes Medical Institute, Boston, Massachusetts, nancy_andrews{at}hms.harvard.edu

Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory mechanisms have evolved to maintain iron homeostasis within cells and between different tissues of complex organisms. This review discusses the proteins involved in iron transport and storage and their regulation in health and disease.

* A. Donovan and C. N. Roy contributed equally to this work.




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