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Physiology 21: 124-133, 2006; doi:10.1152/physiol.00043.2005
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 2, 124-133, April 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Dense-Core Secretory Granule Biogenesis

Taeyoon Kim, Marjorie C. Gondré-Lewis, Irina Arnaoutova and Y. Peng Loh

Section on Cellular Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, lohp{at}mail.nih.gov

The dense-core secretory granule is a key organelle for secretion of hormones and neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and granins are critical for the assembly of these organelles at the trans-Golgi network, and their biogenesis is regulated quantitatively by posttranscriptional and posttranslational mechanisms.




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