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Physiology 21: 171-180, 2006; doi:10.1152/physiol.00003.2006
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Physiology, Vol. 21, No. 3, 171-180, June 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Survival in Hostile Environments: Strategies of Renal Medullary Cells

Wolfgang Neuhofer and Franz-X. Beck

Department of Physiology, University of Munich, Munich, Germany Wolfgang.Neuhofer{at}med.uni-muenchen.de

Cells in the renal medulla exist in a hostile milieu characterized by wide variations in extracellular solute concentrations, low oxygen tensions, and abundant reactive oxygen species. This article reviews the strategies adopted by these cells to allow them to survive and fulfill their functions under these extreme conditions.




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 Am. J. Physiol. Cell Physiol.Home page
D. Steinert, C. Kuper, H. Bartels, F.-X. Beck, and W. Neuhofer
PGE2 potentiates tonicity-induced COX-2 expression in renal medullary cells in a positive feedback loop involving EP2-cAMP-PKA signaling
Am J Physiol Cell Physiol, January 1, 2009; 296(1): C75 - C87.
[Abstract] [Full Text] [PDF]


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