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Physiology 21: 189-196, 2006; doi:10.1152/physiol.00002.2006
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 3, 189-196, June 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Insulin Vesicle Release: Walk, Kiss, Pause ... Then Run

Guy A. Rutter1,2 and Elaine V. Hill1

1 Department of Biochemistry, School of Medical Sciences, University Walk University of Bristol, Bristol
2 Department of Cell Biology, Division of Medicine, Imperial College, London, United Kingdom g.a.rutter{at}bris.ac.uk

The mechanisms by which insulin-containing dense core secretory vesicles approach and finally fuse with the plasma membrane are of considerable current interest: defects in these processes may be one of the contributing factors to Type 2 diabetes. In this review, we discuss the molecular mechanisms involved in vesicle trafficking within the pancreatic ß-cell and the mechanisms whereby these may be regulated. We then go on to describe recent evidence that suggests that vesicle fusion at the plasma membrane is a partly reversible process ("kiss and run" or "cavity recapture"). We propose that vesicles may participate in a exo-endocytotic cycle in which a proportion of those that have already undergone an interaction with the plasma membrane may exchange exocytotic machinery with maturing vesicles.




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