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Physiology 21: 208-215, 2006; doi:10.1152/physiol.00161.2005
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 3, 208-215, June 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Astrocytes Coordinate Synaptic Networks: Balanced Excitation and Inhibition

Tommaso Fellin*, Olivier Pascual* and Philip G. Haydon

Department of Neuroscience, Silvio Conte Center for Integration at the Tripartite Synapse, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania pghaydon{at}mail.med.upenn.edu

Although neurons are essential for brain function, an emerging alternative view holds that astrocytes, the dominant glial cell type, coordinate synaptic networks. Through the release of glutamate, astrocytes locally excite neurons, and via adenosine, which accumulates due to the hydrolysis of released ATP, astrocytes suppress distant synapses.

* T. Fellin and O. Pascual contributed equally to this manuscript.




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