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Physiology 21: 242-249, 2006; doi:10.1152/physiol.00005.2006
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 4, 242-249, August 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Molecular, Functional, and Pathological Aspects of the Mitochondrial ADP/ATP Carrier

C. Dahout-Gonzalez1, H. Nury2, V. Trézéguet3, G. J.-M. Lauquin3, E. Pebay-Peyroula2 and G. Brandolin1

1 Département de Réponse et Dynamique Cellulaires, CEA-Grenoble, Laboratoire de Biochimie et Biophysique des Systèmes Intégrés, UMR 5092 CEA-CNRS-Université Joseph Fourier, Grenoble;
2 Institut de Biologie Structurale Jean-Pierre Ebel, UMR 5075 CEA-CNRS-Université Joseph Fourier, Grenoble; and
3 Institut de Biochimie et Génétique Cellulaires, Laboratoire de Physiologie Moléculaire et Cellulaire, UMR 5095 CNRS-Université Bordeaux 2, Bordeaux, France brandolin{at}cea.fr

In providing the cell with ATP generated by oxidative phosphorylation, the mitochondrial ADP/ATP carrier plays a central role in aerobic eukaryotic cells. Combining biochemical, genetic, and structural approaches contributes to understanding the molecular mechanism of this essential transport system, the dysfunction of which is implicated in neuromuscular diseases.




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