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Physiology 21: 259-268, 2006; doi:10.1152/physiol.00014.2006
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 4, 259-268, August 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Protein-Mediated Fatty Acid Uptake: Novel Insights from In Vivo Models

Holger Doege1 and Andreas Stahl1,2

1 Palo Alto Medical Foundation Research Institute, Palo Alto, and
2 Division of GI/Hepatology, Stanford University School of Medicine, Stanford, California astahl{at}stanford.edu

Long-chain fatty acids are both important metabolites as well as signaling molecules. Fatty acid transport proteins are key mediators of cellular fatty acid uptake and recent transgenic and knockout animal models have provided new insights into their contribution to energy homeostasis and to pathological processes, including obesity and insulin desensitization.




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