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Physiology 21: 307-315, 2006; doi:10.1152/physiol.00021.2006
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 5, 307-315, October 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

EMERGING TECHNOLOGIES

Selenoproteins and Their Impact on Human Health Through Diverse Physiological Pathways

Behzad Moghadaszadeh and Alan H. Beggs

Program in Genomics and Division of Genetics, Children’s Hospital Boston, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, beggs{at}enders.tch.harvard.edu

In the last few decades, the importance of selenium in human health has been the subject of numerous studies. It is believed that the physiological effects of selenium occur mainly through the function of selenoproteins, which incorporate selenium in the form of one or more selenocysteine residues. Recent advances in understanding the complex regulation of selenoprotein synthesis and functional characterization of several members of the selenoprotein family have contributed to an improved comprehension of the role(s) of selenium in human health and the great diversity of physiological pathways influenced by this trace element.




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