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Physiology 21: 346-351, 2006; doi:10.1152/physiol.00013.2006
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 5, 346-351, October 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Remodeling the Plasticity Debate: The Presynaptic Locus Revisited

Stefan Krueger1 and Reiko Maki Fitzsimonds2

1 Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada; and
2 Departments of Cellular and Molecular Physiology, and Neurobiology, Yale University School of Medicine, New Haven, Connecticut stefan.krueger{at}dal.ca

The cellular mechanisms contributing to long-term potentiation and activity-induced formation of glutamatergic synapses have been intensely debated. Recent studies have sparked renewed interest in the role of presynaptic components in these processes. Based on the present evidence, it appears likely that long-term plasticity utilizes both pre- and postsynaptic expression mechanisms.






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