Physiology AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiology 21: 352-361, 2006; doi:10.1152/physiol.00012.2006
1548-9213/06 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cosen-Binker, L. I.
Right arrow Articles by Kapus, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cosen-Binker, L. I.
Right arrow Articles by Kapus, A.
Physiology, Vol. 21, No. 5, 352-361, October 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Cortactin: The Gray Eminence of the Cytoskeleton

Laura I. Cosen-Binker and András Kapus

Saint Michael’s Hospital Research Institute and Department of Surgery, University of Toronto, Toronto, Ontario, Canada, kapusa{at}smh.toronto.on.ca

Cortactin, an actin filament-binding protein and target of multiple kinases, has emerged as a central element connecting signaling pathways with cytoskeleton restructuring. It is involved in a perplexingly diverse array of cellular processes, including cell motility, invasiveness, synaptogenesis, endocytosis, intercellular contact assembly, and host-pathogen interactions, where the common denominator appears to be a role in the coordination of membrane dynamics with cytoskeletal remodeling. Although in recent years our knowledge about cortactin has increased exponentially, the exact mechanisms underlying its fundamental roles remain to be defined.




This article has been cited by other articles:


Home page
 Mol. Biol. CellHome page
F. P.L. Lai, M. Szczodrak, J. M. Oelkers, M. Ladwein, F. Acconcia, S. Benesch, S. Auinger, J. Faix, J. V. Small, S. Polo, et al.
Cortactin Promotes Migration and Platelet-derived Growth Factor-induced Actin Reorganization by Signaling to Rho-GTPases
Mol. Biol. Cell, July 15, 2009; 20(14): 3209 - 3223.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. A. Brown, R. B. Wysolmerski, and P. C. Bridgman
Dorsal Root Ganglion Neurons React to Semaphorin 3A Application through a Biphasic Response that Requires Multiple Myosin II Isoforms
Mol. Biol. Cell, February 1, 2009; 20(4): 1167 - 1179.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
E. K. Hoffmann, I. H. Lambert, and S. F. Pedersen
Physiology of Cell Volume Regulation in Vertebrates
Physiol Rev, January 1, 2009; 89(1): 193 - 277.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
C. Le Clainche and M.-F. Carlier
Regulation of Actin Assembly Associated With Protrusion and Adhesion in Cell Migration
Physiol Rev, April 1, 2008; 88(2): 489 - 513.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. V. Usatyuk, L. H. Romer, D. He, N. L. Parinandi, M. E. Kleinberg, S. Zhan, J. R. Jacobson, S. M. Dudek, S. Pendyala, J. G. N. Garcia, et al.
Regulation of Hyperoxia-induced NADPH Oxidase Activation in Human Lung Endothelial Cells by the Actin Cytoskeleton and Cortactin
J. Biol. Chem., August 10, 2007; 282(32): 23284 - 23295.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2006 by the Int. Union Physiol. Sci./Am. Physiol. Soc.