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Physiology 21: 352-361, 2006; doi:10.1152/physiol.00012.2006
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 5, 352-361, October 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Cortactin: The Gray Eminence of the Cytoskeleton

Laura I. Cosen-Binker and András Kapus

Saint Michael’s Hospital Research Institute and Department of Surgery, University of Toronto, Toronto, Ontario, Canada, kapusa{at}smh.toronto.on.ca

Cortactin, an actin filament-binding protein and target of multiple kinases, has emerged as a central element connecting signaling pathways with cytoskeleton restructuring. It is involved in a perplexingly diverse array of cellular processes, including cell motility, invasiveness, synaptogenesis, endocytosis, intercellular contact assembly, and host-pathogen interactions, where the common denominator appears to be a role in the coordination of membrane dynamics with cytoskeletal remodeling. Although in recent years our knowledge about cortactin has increased exponentially, the exact mechanisms underlying its fundamental roles remain to be defined.




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