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Physiology 21: 430-439, 2006; doi:10.1152/physiol.00032.2006
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 6, 430-439, December 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Lipid Rafts, Detergent-Resistant Membranes, and Raft Targeting Signals

Deborah A. Brown

Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, deborah.brown{at}sunysb.edu

Lipid rafts are liquid-ordered (lo) phase microdomains proposed to exist in biological membranes. Rafts have been widely studied by isolating lo-phase detergent-resistant membranes (DRMs) from cells. Recent findings have shown that DRMs are not the same as preexisting rafts, prompting a major revision of the raft model. Nevertheless, raft-targeting signals identified by DRM analysis are often required for protein function, implicating rafts in a variety of cell processes.




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