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Physiology 22: 30-39, 2007; doi:10.1152/physiol.00035.2006
1548-9213/07 $8.00
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Physiology, Vol. 22, No. 1, 30-39, February 2007
© 2007 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Intracellular pH Sensors: Design Principles and Functional Significance

Jyoti Srivastava1, Diane L. Barber1 and Matthew P. Jacobson2

1 Departments of Cell and Tissue Biology, and
2 Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California diane.barber{at}ucsf.edu

Changes in intracellular pH regulate many cell behaviors, including proliferation, migration, and transformation. However, our understanding of how physiological changes in pH affect protein conformations and macromolecular assemblies is limited. We present design principles, current modeling predictions, and examples of pH sensors or proteins that have activities or ligand-binding affinities that are regulated by changes in intracellular pH.




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