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Physiology 22: 40-46, 2007; doi:10.1152/physiol.00034.2006 Free Article
1548-9213/07 $8.00
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Physiology, Vol. 22, No. 1, 40-46, February 2007
© 2007 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

PKA, Germ Cells, and Fertility

Kimberly A. Burton and G. Stanley McKnight

Department of Pharmacology, University of Washington, Seattle, Washington

Temporal and spatial regulation of PKA activity are essential for vigorous sperm motility and for the resumption of meiosis in oocytes, two events required for successful fertilization. Genetic mutations in mice that affect PKA signaling in germ cells lead to infertility and illustrate the importance of this pathway in mammalian reproduction.




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