Physiology Journal of Applied Physiology
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Physiology 22: 131-144, 2007; doi:10.1152/physiol.00040.2006
1548-9213/07 $8.00
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Physiology, Vol. 22, No. 2, 131-144, April 2007
© 2007 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Ca2+ Signaling in the Inner Ear

Fabio Mammano1,2,3, Mario Bortolozzi1, Saida Ortolano1,3 and Fabio Anselmi2

1 Istituto Veneto di Medicina Molecolare, Fondazione per la Ricerca Biomedica Avanzata, Padova;
2 Centro Interdipartimentale per lo Studio dei Segnali Cellulari, and
3 Dipartimento di Fisica "G.Galilei", Università di Padova, Padova, Italy fabio.mammano{at}unipd.it

The inner ear contains delicate sensory receptors that have adapted to detect the minutest mechanical disturbances. Ca2+ ions are implicated in all steps of the transduction process, as well as in its regulation by an impressive ensemble of finely tuned feedback control mechanisms. Recent studies have unveiled some of the key players, but things do not sound quite right yet.






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