Physiology AJP: Gastrointestinal and Liver Physiology
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Physiology 22: 167-173, 2007; doi:10.1152/physiol.00005.2007
1548-9213/07 $8.00
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Physiology, Vol. 22, No. 3, 167-173, June 2007
© 2007 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Resurgence of Cardiac T-Tubule Research

Fabien Brette1 and Clive Orchard2

1 Faculty of Life Sciences, University of Manchester, Manchester; and
2 Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom f.brette{at}manchester.ac.uk

The transverse tubules of mammalian cardiac ventricular myocytes are invaginations of the surface membrane. Recent data have revealed that their structure and function are more complex than previously believed. Here, we review current knowledge about their role in cardiac function, focusing on Ca2+ signaling and changes observed in pathological conditions.






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