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REVIEW

Resurgence of Cardiac T-Tubule Research

Fabien Brette¹ and Clive Orchard²

¹ Faculty of Life Sciences, University of Manchester, Manchester; and
² Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom f.brette{at}manchester.ac.uk

The transverse tubules of mammalian cardiac ventricular myocytes are invaginations of the surface membrane. Recent data have revealed that their structure and function are more complex than previously believed. Here, we review current knowledge about their role in cardiac function, focusing on Ca²⁺ signaling and changes observed in pathological conditions.

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