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Physiology 22: 185-192, 2007; doi:10.1152/physiol.00001.2007
1548-9213/07 $8.00
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Physiology, Vol. 22, No. 3, 185-192, June 2007
© 2007 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

K+-Dependent Na+/Ca2+ Exchangers: Key Contributors to Ca2+ Signaling

Frank Visser and Jonathan Lytton

Department of Biochemistry and Molecular Biology, Libin Cardiovascular Institute of Alberta and the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada jlytton{at}ucalgary.ca

An elevation in cytosolic Ca2+ is a universal signaling mechanism that controls a vast array of physiological processes. K+-dependent Na+/Ca2+ exchangers are a newly identified family of Ca2+ efflux transporters that play important and diverse roles in cellular Ca2+ homeostasis.






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